| Date | Opponents | Comp | Res | Venue |
|---|---|---|---|---|
| Sat 18 Aug 1951 | Liverpool | League | W 2-0 | Anfield |
| Wed 22 Aug 1951 | BLACKPOOL | League | L 1-3 | Fratton Park |
| Sat 25 Aug 1951 | CHARLTON ATHLETIC | League | W 1-0 | Fratton Park |
| Mon 27 Aug 1951 | Blackpool | League | D 0-0 | Bloomfield Road |
| Sat 01 Sep 1951 | CHELSEA | League | W 1-0 | Fratton Park |
| Wed 05 Sep 1951 | MANCHESTER CITY | League | W 1-0 | Fratton Park |
| Sat 08 Sep 1951 | Huddersfield Town | League | W 1-0 | Leeds Road |
| Sat 15 Sep 1951 | WOLVERHAMPTON WANDERERS | League | L 2-3 | Fratton Park |
| Sat 22 Sep 1951 | Sunderland | League | L 1-3 | Roker Park |
| Sat 29 Sep 1951 | ASTON VILLA | League | W 2-0 | Fratton Park |
| Sat 06 Oct 1951 | Fulham | League | W 3-2 | Craven Cottage |
| Sat 13 Oct 1951 | MIDDLESBROUGH | League | W 5-4 | Fratton Park |
| Sat 20 Oct 1951 | West Bromwich Albion | League | L 0-5 | The Hawthorns |
| Sat 27 Oct 1951 | NEWCASTLE UNITED | League | W 3-1 | Fratton Park |
| Sat 03 Nov 1951 | Bolton Wanderers | League | W 3-0 | Burnden Park |
| Sat 10 Nov 1951 | STOKE CITY | League | W 4-1 | Fratton Park |
| Sat 17 Nov 1951 | Manchester United | League | W 3-1 | Old Trafford |
| Sat 24 Nov 1951 | TOTTENHAM HOTSPUR | League | W 2-0 | Fratton Park |
| Sat 01 Dec 1951 | Preston North End | League | D 2-2 | Deepdale |
| Sat 08 Dec 1951 | BURNLEY | League | D 2-2 | Fratton Park |
| Sat 15 Dec 1951 | LIVERPOOL | League | L 1-3 | Fratton Park |
| Sat 22 Dec 1951 | Charlton Athletic | League | W 2-0 | The Valley |
| Tue 25 Dec 1951 | Arsenal | League | L 1-4 | Highbury |
| Wed 26 Dec 1951 | ARSENAL | League | D 1-1 | Fratton Park |
| Sat 29 Dec 1951 | Chelsea | League | D 1-1 | Stamford Bridge |
| Tue 01 Jan 1952 | Manchester City | League | W 1-0 | Maine Road |
| Sat 05 Jan 1952 | HUDDERSFIELD TOWN | League | W 3-1 | Fratton Park |
| Sat 19 Jan 1952 | Wolverhampton Wanderers | League | D 1-1 | Molineux |
| Sat 26 Jan 1952 | SUNDERLAND | League | L 0-2 | Fratton Park |
| Sat 09 Feb 1952 | Aston Villa | League | L 0-2 | Villa Park |
| Sat 16 Feb 1952 | FULHAM | League | W 4-0 | Fratton Park |
| Sat 01 Mar 1952 | Middlesbrough | League | L 1-2 | Ayresome Park |
| Wed 12 Mar 1952 | WEST BROMWICH ALBION | League | D 1-1 | Fratton Park |
| Sat 15 Mar 1952 | Newcastle United | League | D 3-3 | St. James Park |
| Sat 22 Mar 1952 | BOLTON WANDERERS | League | W 3-0 | Fratton Park |
| Sat 29 Mar 1952 | Stoke City | League | L 0-2 | Victoria Ground |
| Sat 05 Apr 1952 | MANCHESTER UNITED | League | W 1-0 | Fratton Park |
| Fri 11 Apr 1952 | DERBY COUNTY | League | W 3-1 | Fratton Park |
| Sat 12 Apr 1952 | Tottenham Hotspur | League | L 1-3 | White Hart Lane |
| Mon 14 Apr 1952 | Derby County | League | L 0-1 | Baseball Ground |
| Sat 19 Apr 1952 | PRESTON NORTH END | League | L 1-2 | Fratton Park |
| Sat 26 Apr 1952 | Burnley | League | L 0-1 | Turf Moor |