| Date | Opponents | Comp | Res | Venue |
|---|---|---|---|---|
| Sat 23 Aug 1952 | BLACKPOOL | League | L 0-2 | Fratton Park |
| Wed 27 Aug 1952 | Charlton Athletic | League | D 2-2 | The Valley |
| Sat 30 Aug 1952 | Chelsea | League | L 0-2 | Stamford Bridge |
| Wed 03 Sep 1952 | CHARLTON ATHLETIC | League | D 1-1 | Fratton Park |
| Sat 06 Sep 1952 | MANCHESTER UNITED | League | W 2-0 | Fratton Park |
| Wed 10 Sep 1952 | Arsenal | League | L 1-3 | Highbury |
| Sat 13 Sep 1952 | Liverpool | League | D 1-1 | Anfield |
| Wed 17 Sep 1952 | ARSENAL | League | D 2-2 | Fratton Park |
| Sat 20 Sep 1952 | Bolton Wanderers | League | W 5-0 | Burnden Park |
| Sat 27 Sep 1952 | ASTON VILLA | League | D 1-1 | Fratton Park |
| Sat 04 Oct 1952 | Sunderland | League | D 1-1 | Roker Park |
| Sat 11 Oct 1952 | MANCHESTER CITY | League | W 2-1 | Fratton Park |
| Sat 18 Oct 1952 | Stoke City | League | W 4-2 | Victoria Ground |
| Sat 25 Oct 1952 | PRESTON NORTH END | League | L 2-5 | Fratton Park |
| Sat 01 Nov 1952 | Burnley | League | L 2-3 | Turf Moor |
| Sat 08 Nov 1952 | TOTTENHAM HOTSPUR | League | W 2-1 | Fratton Park |
| Sat 15 Nov 1952 | Sheffield Wednesday | League | W 4-3 | Hillsborough |
| Sat 22 Nov 1952 | CARDIFF CITY | League | L 0-2 | Fratton Park |
| Sat 29 Nov 1952 | Newcastle United | League | L 0-1 | St. James Park |
| Sat 06 Dec 1952 | WEST BROMWICH ALBION | League | L 1-2 | Fratton Park |
| Sat 13 Dec 1952 | Middlesbrough | League | L 2-3 | Ayresome Park |
| Sat 20 Dec 1952 | Blackpool | League | L 2-3 | Bloomfield Road |
| Fri 26 Dec 1952 | Derby County | League | L 0-3 | Baseball Ground |
| Sat 27 Dec 1952 | DERBY COUNTY | League | D 2-2 | Fratton Park |
| Sat 03 Jan 1953 | CHELSEA | League | W 2-0 | Fratton Park |
| Sat 17 Jan 1953 | Manchester United | League | L 0-1 | Old Trafford |
| Sat 24 Jan 1953 | LIVERPOOL | League | W 3-1 | Fratton Park |
| Sat 07 Feb 1953 | BOLTON WANDERERS | League | W 3-1 | Fratton Park |
| Wed 18 Feb 1953 | Aston Villa | League | L 0-6 | Villa Park |
| Sat 21 Feb 1953 | SUNDERLAND | League | W 5-2 | Fratton Park |
| Sat 28 Feb 1953 | Manchester City | League | L 1-2 | Maine Road |
| Sat 07 Mar 1953 | STOKE CITY | League | D 1-1 | Fratton Park |
| Sat 14 Mar 1953 | Preston North End | League | L 0-4 | Deepdale |
| Sat 21 Mar 1953 | BURNLEY | League | W 2-1 | Fratton Park |
| Sat 28 Mar 1953 | Tottenham Hotspur | League | D 3-3 | White Hart Lane |
| Fri 03 Apr 1953 | WOLVERHAMPTON WANDERERS | League | D 2-2 | Fratton Park |
| Sat 04 Apr 1953 | SHEFFIELD WEDNESDAY | League | W 5-2 | Fratton Park |
| Mon 06 Apr 1953 | Wolverhampton Wanderers | League | L 1-4 | Molineux |
| Sat 11 Apr 1953 | Cardiff City | League | W 1-0 | Ninian Park |
| Sat 18 Apr 1953 | NEWCASTLE UNITED | League | W 5-1 | Fratton Park |
| Sat 25 Apr 1953 | West Bromwich Albion | League | L 0-2 | The Hawthorns |
| Sat 02 May 1953 | MIDDLESBROUGH | League | L 1-4 | Fratton Park |