| Date | Opponents | Type | Res/KO | Venue |
|---|---|---|---|---|
| Sat 12 Aug 1972 | Nottingham Forest | League | D 0-0 | City Ground |
| Sat 19 Aug 1972 | CARDIFF CITY | League | W 3-1 | Fratton Park |
| Sat 26 Aug 1972 | Millwall | League | W 2-0 | The Den (old) |
| Wed 30 Aug 1972 | HUDDERSFIELD TOWN | League | L 1-2 | Fratton Park |
| Sat 02 Sep 1972 | BURNLEY | League | L 0-2 | Fratton Park |
| Sat 09 Sep 1972 | Sheffield Wednesday | League | L 1-2 | Hillsborough |
| Sat 16 Sep 1972 | PRESTON NORTH END | League | L 0-1 | Fratton Park |
| Sat 23 Sep 1972 | Swindon Town | League | D 1-1 | County Ground |
| Wed 27 Sep 1972 | OXFORD UNITED | League | W 1-0 | Fratton Park |
| Sat 30 Sep 1972 | BRIGHTON & HOVE ALBION | League | W 2-0 | Fratton Park |
| Sat 07 Oct 1972 | BRISTOL CITY | League | L 0-3 | Fratton Park |
| Sat 14 Oct 1972 | Hull City | League | L 1-5 | Boothferry Park |
| Wed 18 Oct 1972 | Luton Town | League | D 2-2 | Kenilworth Road |
| Sat 21 Oct 1972 | ASTON VILLA | League | L 0-1 | Fratton Park |
| Sat 28 Oct 1972 | Carlisle United | League | L 0-1 | Brunton Park |
| Sat 04 Nov 1972 | Oxford United | League | W 3-1 | Manor Ground |
| Sat 11 Nov 1972 | LUTON TOWN | League | D 2-2 | Fratton Park |
| Sat 18 Nov 1972 | Fulham | League | D 0-0 | Craven Cottage |
| Sat 25 Nov 1972 | QUEENS PARK RANGERS | League | L 0-1 | Fratton Park |
| Sat 02 Dec 1972 | Blackpool | League | L 1-3 | Bloomfield Road |
| Sat 09 Dec 1972 | SUNDERLAND | League | L 2-3 | Fratton Park |
| Sat 16 Dec 1972 | MIDDLESBROUGH | League | D 0-0 | Fratton Park |
| Sat 23 Dec 1972 | Orient | League | W 1-0 | Brisbane Road |
| Tue 26 Dec 1972 | SWINDON TOWN | League | D 1-1 | Fratton Park |
| Fri 29 Dec 1972 | Cardiff City | League | W 2-0 | Ninian Park |
| Sat 06 Jan 1973 | MILLWALL | League | D 1-1 | Fratton Park |
| Sat 27 Jan 1973 | SHEFFIELD WEDNESDAY | League | W 1-0 | Fratton Park |
| Sat 10 Feb 1973 | Preston North End | League | W 5-0 | Deepdale |
| Sat 17 Feb 1973 | NOTTINGHAM FOREST | League | W 2-0 | Fratton Park |
| Sat 24 Feb 1973 | Middlesbrough | League | L 0-3 | Ayresome Park |
| Sat 03 Mar 1973 | Bristol City | League | L 1-3 | Ashton Gate |
| Sat 10 Mar 1973 | HULL CITY | League | D 2-2 | Fratton Park |
| Sat 17 Mar 1973 | Aston Villa | League | L 0-2 | Villa Park |
| Tue 20 Mar 1973 | Burnley | League | L 0-4 | Turf Moor |
| Sat 24 Mar 1973 | CARLISLE UNITED | League | D 0-0 | Fratton Park |
| Sat 31 Mar 1973 | Queens Park Rangers | League | L 0-5 | Loftus Road |
| Sat 07 Apr 1973 | BLACKPOOL | League | W 1-0 | Fratton Park |
| Sat 14 Apr 1973 | Sunderland | League | L 0-2 | Roker Park |
| Fri 20 Apr 1973 | ORIENT | League | W 1-0 | Fratton Park |
| Sat 21 Apr 1973 | FULHAM | League | L 1-2 | Fratton Park |
| Mon 23 Apr 1973 | Brighton & Hove Albion | League | D 1-1 | Goldstone Ground |
| Sat 28 Apr 1973 | Huddersfield Town | League | L 0-2 | Leeds Road |