| Date | Opponents | Comp | Res | Venue |
|---|---|---|---|---|
| Sat 21 Aug 1948 | Preston North End | League | D 2-2 | Deepdale |
| Wed 25 Aug 1948 | EVERTON | League | W 4-0 | Fratton Park |
| Sat 28 Aug 1948 | BURNLEY | League | W 1-0 | Fratton Park |
| Wed 01 Sep 1948 | Everton | League | W 5-0 | Goodison Park |
| Sat 04 Sep 1948 | Stoke City | League | W 1-0 | Victoria Ground |
| Wed 08 Sep 1948 | MIDDLESBROUGH | League | W 1-0 | Fratton Park |
| Sat 11 Sep 1948 | CHARLTON ATHLETIC | League | W 3-1 | Fratton Park |
| Wed 15 Sep 1948 | Middlesbrough | League | D 1-1 | Ayresome Park |
| Sat 18 Sep 1948 | Manchester City | League | D 1-1 | Maine Road |
| Sat 25 Sep 1948 | SHEFFIELD UNITED | League | W 3-0 | Fratton Park |
| Sat 02 Oct 1948 | NEWCASTLE UNITED | League | W 1-0 | Fratton Park |
| Sat 09 Oct 1948 | Aston Villa | League | D 1-1 | Villa Park |
| Sat 16 Oct 1948 | SUNDERLAND | League | W 3-0 | Fratton Park |
| Sat 23 Oct 1948 | Wolverhampton Wanderers | League | L 0-3 | Molineux |
| Sat 30 Oct 1948 | BOLTON WANDERERS | League | D 0-0 | Fratton Park |
| Sat 06 Nov 1948 | Liverpool | League | L 1-3 | Anfield |
| Sat 13 Nov 1948 | BLACKPOOL | League | D 1-1 | Fratton Park |
| Sat 20 Nov 1948 | Derby County | League | L 0-1 | Baseball Ground |
| Sat 27 Nov 1948 | ARSENAL | League | W 4-1 | Fratton Park |
| Sat 04 Dec 1948 | Huddersfield Town | League | D 0-0 | Leeds Road |
| Sat 11 Dec 1948 | MANCHESTER UNITED | League | D 2-2 | Fratton Park |
| Sat 18 Dec 1948 | PRESTON NORTH END | League | W 3-1 | Fratton Park |
| Sat 25 Dec 1948 | Chelsea | League | W 2-1 | Stamford Bridge |
| Mon 27 Dec 1948 | CHELSEA | League | W 5-2 | Fratton Park |
| Sat 01 Jan 1949 | Burnley | League | L 1-2 | Turf Moor |
| Sat 15 Jan 1949 | STOKE CITY | League | W 1-0 | Fratton Park |
| Sat 22 Jan 1949 | Charlton Athletic | League | W 1-0 | The Valley |
| Sat 05 Feb 1949 | MANCHESTER CITY | League | W 3-1 | Fratton Park |
| Sat 19 Feb 1949 | Sheffield United | League | L 1-3 | Bramall Lane |
| Sat 05 Mar 1949 | ASTON VILLA | League | W 3-0 | Fratton Park |
| Sat 12 Mar 1949 | Sunderland | League | W 4-1 | Roker Park |
| Sat 19 Mar 1949 | DERBY COUNTY | League | W 1-0 | Fratton Park |
| Sat 02 Apr 1949 | LIVERPOOL | League | W 3-2 | Fratton Park |
| Wed 06 Apr 1949 | Newcastle United | League | W 5-0 | St. James Park |
| Sat 09 Apr 1949 | Blackpool | League | L 0-1 | Bloomfield Road |
| Fri 15 Apr 1949 | BIRMINGHAM CITY | League | W 3-1 | Fratton Park |
| Sat 16 Apr 1949 | WOLVERHAMPTON WANDERERS | League | W 5-0 | Fratton Park |
| Mon 18 Apr 1949 | Birmingham City | League | L 0-3 | St. Andrews |
| Sat 23 Apr 1949 | Bolton Wanderers | League | W 2-1 | Burnden Park |
| Sat 30 Apr 1949 | HUDDERSFIELD TOWN | League | W 2-0 | Fratton Park |
| Wed 04 May 1949 | Arsenal | League | L 2-3 | Highbury |
| Sat 07 May 1949 | Manchester United | League | L 2-3 | Maine Road |
