| Date | Opponents | Comp | Res | Venue |
|---|---|---|---|---|
| Sat 20 Aug 1949 | Newcastle United | League | W 3-1 | St. James Park |
| Wed 24 Aug 1949 | MANCHESTER CITY | League | D 1-1 | Fratton Park |
| Sat 27 Aug 1949 | BLACKPOOL | League | L 2-3 | Fratton Park |
| Wed 31 Aug 1949 | Manchester City | League | L 0-1 | Maine Road |
| Sat 03 Sep 1949 | Middlesbrough | League | W 5-1 | Ayresome Park |
| Mon 05 Sep 1949 | Aston Villa | League | L 0-1 | Villa Park |
| Sat 10 Sep 1949 | EVERTON | League | W 7-0 | Fratton Park |
| Sat 17 Sep 1949 | Huddersfield Town | League | W 1-0 | Leeds Road |
| Sat 24 Sep 1949 | BOLTON WANDERERS | League | D 1-1 | Fratton Park |
| Sat 01 Oct 1949 | WOLVERHAMPTON WANDERERS | League | D 1-1 | Fratton Park |
| Sat 08 Oct 1949 | Birmingham City | League | W 3-0 | St. Andrews |
| Sat 15 Oct 1949 | DERBY COUNTY | League | W 3-1 | Fratton Park |
| Sat 22 Oct 1949 | West Bromwich Albion | League | L 0-3 | The Hawthorns |
| Sat 29 Oct 1949 | MANCHESTER UNITED | League | D 0-0 | Fratton Park |
| Sat 05 Nov 1949 | Chelsea | League | W 4-1 | Stamford Bridge |
| Sat 12 Nov 1949 | STOKE CITY | League | D 0-0 | Fratton Park |
| Sat 19 Nov 1949 | Burnley | League | L 1-2 | Turf Moor |
| Sat 26 Nov 1949 | SUNDERLAND | League | D 2-2 | Fratton Park |
| Sat 03 Dec 1949 | Liverpool | League | D 2-2 | Anfield |
| Sat 10 Dec 1949 | ARSENAL | League | W 2-1 | Fratton Park |
| Sat 17 Dec 1949 | NEWCASTLE UNITED | League | W 1-0 | Fratton Park |
| Sat 24 Dec 1949 | Blackpool | League | L 1-2 | Bloomfield Road |
| Mon 26 Dec 1949 | Charlton Athletic | League | W 2-1 | The Valley |
| Tue 27 Dec 1949 | CHARLTON ATHLETIC | League | W 1-0 | Fratton Park |
| Sat 31 Dec 1949 | MIDDLESBROUGH | League | D 1-1 | Fratton Park |
| Sat 14 Jan 1950 | Everton | League | W 2-1 | Goodison Park |
| Sat 21 Jan 1950 | HUDDERSFIELD TOWN | League | W 4-0 | Fratton Park |
| Sat 04 Feb 1950 | Bolton Wanderers | League | L 0-1 | Burnden Park |
| Sat 18 Feb 1950 | Wolverhampton Wanderers | League | L 0-1 | Molineux |
| Sat 25 Feb 1950 | BIRMINGHAM CITY | League | W 2-0 | Fratton Park |
| Wed 08 Mar 1950 | Derby County | League | L 1-2 | Baseball Ground |
| Sat 11 Mar 1950 | BURNLEY | League | W 2-1 | Fratton Park |
| Sat 18 Mar 1950 | Sunderland | League | D 1-1 | Roker Park |
| Sat 25 Mar 1950 | CHELSEA | League | W 4-0 | Fratton Park |
| Sat 01 Apr 1950 | Stoke City | League | W 1-0 | Victoria Ground |
| Fri 07 Apr 1950 | FULHAM | League | W 3-0 | Fratton Park |
| Sat 08 Apr 1950 | WEST BROMWICH ALBION | League | L 0-1 | Fratton Park |
| Mon 10 Apr 1950 | Fulham | League | W 1-0 | Craven Cottage |
| Sat 15 Apr 1950 | Manchester United | League | W 2-0 | Old Trafford |
| Sat 22 Apr 1950 | LIVERPOOL | League | W 2-1 | Fratton Park |
| Wed 03 May 1950 | Arsenal | League | L 0-2 | Highbury |
| Sat 06 May 1950 | ASTON VILLA | League | W 5-1 | Fratton Park |
