| Date | Opponents | Comp | Res | Venue |
|---|---|---|---|---|
| Sat 19 Aug 1950 | MIDDLESBROUGH | League | D 1-1 | Fratton Park |
| Mon 21 Aug 1950 | Sheffield Wednesday | League | L 1-2 | Hillsborough |
| Sat 26 Aug 1950 | Huddersfield Town | League | L 1-2 | Leeds Road |
| Wed 30 Aug 1950 | SHEFFIELD WEDNESDAY | League | W 4-1 | Fratton Park |
| Sat 02 Sep 1950 | NEWCASTLE UNITED | League | D 0-0 | Fratton Park |
| Mon 04 Sep 1950 | Burnley | League | D 1-1 | Turf Moor |
| Sat 09 Sep 1950 | West Bromwich Albion | League | L 0-5 | The Hawthorns |
| Sat 16 Sep 1950 | STOKE CITY | League | W 5-1 | Fratton Park |
| Sat 23 Sep 1950 | Everton | League | W 5-1 | Goodison Park |
| Sat 30 Sep 1950 | FULHAM | League | W 1-0 | Fratton Park |
| Sat 07 Oct 1950 | Bolton Wanderers | League | L 0-4 | Burnden Park |
| Sat 14 Oct 1950 | BLACKPOOL | League | W 2-0 | Fratton Park |
| Sat 21 Oct 1950 | Manchester United | League | D 0-0 | Old Trafford |
| Sat 28 Oct 1950 | WOLVERHAMPTON WANDERERS | League | L 1-4 | Fratton Park |
| Sat 04 Nov 1950 | Tottenham Hotspur | League | L 1-5 | White Hart Lane |
| Sat 11 Nov 1950 | CHARLTON ATHLETIC | League | D 3-3 | Fratton Park |
| Sat 18 Nov 1950 | Sunderland | League | D 0-0 | Roker Park |
| Sat 25 Nov 1950 | ASTON VILLA | League | D 3-3 | Fratton Park |
| Sat 02 Dec 1950 | Derby County | League | W 3-2 | Baseball Ground |
| Sat 09 Dec 1950 | LIVERPOOL | League | L 1-3 | Fratton Park |
| Sat 16 Dec 1950 | Middlesbrough | League | L 1-3 | Ayresome Park |
| Sat 23 Dec 1950 | HUDDERSFIELD TOWN | League | W 1-0 | Fratton Park |
| Mon 25 Dec 1950 | CHELSEA | League | L 1-3 | Fratton Park |
| Tue 26 Dec 1950 | Chelsea | League | W 4-1 | Stamford Bridge |
| Sat 13 Jan 1951 | WEST BROMWICH ALBION | League | D 2-2 | Fratton Park |
| Sat 20 Jan 1951 | Stoke City | League | W 2-1 | Victoria Ground |
| Sat 03 Feb 1951 | EVERTON | League | W 6-3 | Fratton Park |
| Sat 10 Feb 1951 | Liverpool | League | L 1-2 | Anfield |
| Sat 24 Feb 1951 | BOLTON WANDERERS | League | W 2-1 | Fratton Park |
| Sat 03 Mar 1951 | Blackpool | League | L 0-3 | Bloomfield Road |
| Sat 10 Mar 1951 | MANCHESTER UNITED | League | D 0-0 | Fratton Park |
| Sat 17 Mar 1951 | Wolverhampton Wanderers | League | W 3-2 | Molineux |
| Fri 23 Mar 1951 | Arsenal | League | W 1-0 | Highbury |
| Sat 24 Mar 1951 | TOTTENHAM HOTSPUR | League | D 1-1 | Fratton Park |
| Mon 26 Mar 1951 | ARSENAL | League | D 1-1 | Fratton Park |
| Sat 31 Mar 1951 | Charlton Athletic | League | W 1-0 | The Valley |
| Sat 07 Apr 1951 | SUNDERLAND | League | D 0-0 | Fratton Park |
| Wed 11 Apr 1951 | Newcastle United | League | D 0-0 | St. James Park |
| Sat 14 Apr 1951 | Aston Villa | League | D 3-3 | Villa Park |
| Sat 21 Apr 1951 | DERBY COUNTY | League | D 2-2 | Fratton Park |
| Wed 02 May 1951 | Fulham | League | W 4-1 | Craven Cottage |
| Sat 05 May 1951 | BURNLEY | League | W 2-1 | Fratton Park |
