| Date | Opponents | Comp | Res | Venue |
|---|---|---|---|---|
| Sat 24 Aug 1957 | BURNLEY | League | D 0-0 | Fratton Park |
| Wed 28 Aug 1957 | TOTTENHAM HOTSPUR | League | W 5-1 | Fratton Park |
| Sat 31 Aug 1957 | Preston North End | League | L 0-4 | Deepdale |
| Wed 04 Sep 1957 | Tottenham Hotspur | League | W 5-3 | White Hart Lane |
| Sat 07 Sep 1957 | SHEFFIELD WEDNESDAY | League | W 3-2 | Fratton Park |
| Wed 11 Sep 1957 | Newcastle United | League | L 0-2 | St. James Park |
| Sat 14 Sep 1957 | Manchester City | League | L 1-2 | Maine Road |
| Wed 18 Sep 1957 | NEWCASTLE UNITED | League | D 2-2 | Fratton Park |
| Sat 21 Sep 1957 | NOTTINGHAM FOREST | League | L 1-4 | Fratton Park |
| Sat 28 Sep 1957 | Bolton Wanderers | League | L 0-1 | Burnden Park |
| Sat 05 Oct 1957 | West Bromwich Albion | League | L 1-3 | The Hawthorns |
| Sat 12 Oct 1957 | LEEDS UNITED | League | L 1-2 | Fratton Park |
| Sat 19 Oct 1957 | Manchester United | League | W 3-0 | Old Trafford |
| Sat 26 Oct 1957 | LEICESTER CITY | League | W 2-0 | Fratton Park |
| Sat 02 Nov 1957 | Aston Villa | League | L 1-2 | Villa Park |
| Sat 09 Nov 1957 | WOLVERHAMPTON WANDERERS | League | D 1-1 | Fratton Park |
| Sat 16 Nov 1957 | Arsenal | League | L 2-3 | Highbury |
| Sat 23 Nov 1957 | EVERTON | League | W 3-2 | Fratton Park |
| Sat 30 Nov 1957 | Blackpool | League | L 1-2 | Bloomfield Road |
| Sat 07 Dec 1957 | LUTON TOWN | League | W 5-0 | Fratton Park |
| Sat 14 Dec 1957 | Sunderland | League | D 1-1 | Roker Park |
| Sat 21 Dec 1957 | Burnley | League | L 1-3 | Turf Moor |
| Wed 25 Dec 1957 | Chelsea | League | L 4-7 | Stamford Bridge |
| Thu 26 Dec 1957 | CHELSEA | League | W 3-0 | Fratton Park |
| Sat 28 Dec 1957 | PRESTON NORTH END | League | L 0-2 | Fratton Park |
| Sat 11 Jan 1958 | Sheffield Wednesday | League | L 2-4 | Hillsborough |
| Sat 18 Jan 1958 | MANCHESTER CITY | League | W 2-1 | Fratton Park |
| Sat 01 Feb 1958 | Nottingham Forest | League | L 0-2 | City Ground |
| Sat 08 Feb 1958 | BOLTON WANDERERS | League | D 2-2 | Fratton Park |
| Sat 22 Feb 1958 | Leeds United | League | L 0-2 | Elland Road |
| Sat 08 Mar 1958 | Leicester City | League | D 2-2 | Filbert Street |
| Sat 15 Mar 1958 | ASTON VILLA | League | W 1-0 | Fratton Park |
| Wed 19 Mar 1958 | WEST BROMWICH ALBION | League | D 2-2 | Fratton Park |
| Sat 22 Mar 1958 | Everton | League | L 2-4 | Goodison Park |
| Sat 29 Mar 1958 | ARSENAL | League | W 5-4 | Fratton Park |
| Fri 04 Apr 1958 | BIRMINGHAM CITY | League | W 3-2 | Fratton Park |
| Sat 05 Apr 1958 | Wolverhampton Wanderers | League | L 0-1 | Molineux |
| Mon 07 Apr 1958 | Birmingham City | League | L 1-4 | St. Andrews |
| Sat 12 Apr 1958 | BLACKPOOL | League | L 1-2 | Fratton Park |
| Wed 16 Apr 1958 | MANCHESTER UNITED | League | D 3-3 | Fratton Park |
| Sat 19 Apr 1958 | Luton Town | League | L 1-2 | Kenilworth Road |
| Sat 26 Apr 1958 | SUNDERLAND | League | L 0-2 | Fratton Park |
