| Date | Opponents | Type | Res/KO | Venue |
|---|---|---|---|---|
| Sat 20 Aug 1960 | LINCOLN CITY | League | W 3-0 | Fratton Park |
| Wed 24 Aug 1960 | Luton Town | League | L 0-1 | Kenilworth Road |
| Sat 27 Aug 1960 | Southampton | League | L 1-5 | The Dell |
| Wed 31 Aug 1960 | LUTON TOWN | League | W 3-2 | Fratton Park |
| Sat 03 Sep 1960 | Huddersfield Town | League | D 3-3 | Leeds Road |
| Wed 07 Sep 1960 | STOKE CITY | League | W 1-0 | Fratton Park |
| Sat 10 Sep 1960 | SUNDERLAND | League | W 2-1 | Fratton Park |
| Mon 12 Sep 1960 | Stoke City | League | L 0-1 | Victoria Ground |
| Sat 17 Sep 1960 | Plymouth Argyle | League | L 1-5 | Home Park |
| Tue 20 Sep 1960 | Sheffield United | League | L 1-3 | Bramall Lane |
| Sat 24 Sep 1960 | NORWICH CITY | League | W 3-0 | Fratton Park |
| Sat 01 Oct 1960 | Charlton Athletic | League | L 4-7 | The Valley |
| Sat 08 Oct 1960 | ROTHERHAM UNITED | League | D 2-2 | Fratton Park |
| Sat 15 Oct 1960 | Liverpool | League | D 3-3 | Anfield |
| Sat 29 Oct 1960 | Derby County | League | L 2-6 | Baseball Ground |
| Sat 05 Nov 1960 | LEYTON ORIENT | League | L 1-2 | Fratton Park |
| Sat 12 Nov 1960 | Scunthorpe United | League | L 1-5 | Old Showground |
| Sat 19 Nov 1960 | IPSWICH TOWN | League | W 1-0 | Fratton Park |
| Sat 26 Nov 1960 | Brighton & Hove Albion | League | D 2-2 | Goldstone Ground |
| Sat 10 Dec 1960 | Leeds United | League | D 0-0 | Elland Road |
| Sat 17 Dec 1960 | Lincoln City | League | W 3-2 | Sincil Bank |
| Mon 26 Dec 1960 | Swansea Town | League | L 0-4 | Vetch Field |
| Tue 27 Dec 1960 | SWANSEA TOWN | League | D 1-1 | Fratton Park |
| Sat 31 Dec 1960 | SOUTHAMPTON | League | D 1-1 | Fratton Park |
| Sat 14 Jan 1961 | HUDDERSFIELD TOWN | League | L 1-3 | Fratton Park |
| Sat 21 Jan 1961 | Sunderland | League | L 1-4 | Roker Park |
| Sat 28 Jan 1961 | MIDDLESBROUGH | League | L 0-3 | Fratton Park |
| Sat 04 Feb 1961 | PLYMOUTH ARGYLE | League | L 0-2 | Fratton Park |
| Sat 11 Feb 1961 | Norwich City | League | L 1-3 | Carrow Road |
| Sat 18 Feb 1961 | CHARLTON ATHLETIC | League | D 1-1 | Fratton Park |
| Sat 25 Feb 1961 | Rotherham United | League | L 0-1 | Millmoor |
| Sat 04 Mar 1961 | LIVERPOOL | League | D 2-2 | Fratton Park |
| Sat 11 Mar 1961 | Bristol Rovers | League | L 0-2 | Eastville Stadium |
| Sat 18 Mar 1961 | LEEDS UNITED | League | W 3-1 | Fratton Park |
| Sat 25 Mar 1961 | Leyton Orient | League | L 1-2 | Brisbane Road |
| Sat 01 Apr 1961 | BRIGHTON & HOVE ALBION | League | W 4-0 | Fratton Park |
| Mon 03 Apr 1961 | SHEFFIELD UNITED | League | L 1-2 | Fratton Park |
| Sat 08 Apr 1961 | Ipswich Town | League | D 2-2 | Portman Road |
| Sat 15 Apr 1961 | SCUNTHORPE UNITED | League | D 2-2 | Fratton Park |
| Wed 19 Apr 1961 | BRISTOL ROVERS | League | W 3-0 | Fratton Park |
| Sat 22 Apr 1961 | Middlesbrough | League | L 0-3 | Ayresome Park |
| Sat 29 Apr 1961 | DERBY COUNTY | League | W 3-2 | Fratton Park |
